The goal of this study was to improve the understanding of the soil-structure interaction mechanisms at the interface of bored concrete piles cast in sandy soils. In addition, this study aimed to quantify the interface shear strength and identify the factors that influence the response. Roughness measurements and direct shear tests were performed at the interface between two samples of sand (medium and coarse) and concrete cured under stress. The influence of the mean grain diameter, relative density, water content, concrete curing time and normal stress on the interface shear strength were statistically analyzed. The results showed a consistent behavior with the technical literature, but with higher values, which can be attributed to the concrete curing time, a factor not studied by other authors.